Dogok-dong Dermatology: Cases Where We Do Not Recommend Re2O

Hello.

I am Dr. Dajeong Kim, Chief Medical Director at Cordia Clinic.

Lately, we have been hearing questions like these quite often in our Dogok-dong clinic:

"Director, what about Re2O? Is it really that great?" ​ "I saw on Instagram that it looks very natural when injected into the cheeks—would it work well for me too?"

To be completely honest, my answer is always the same:

"It depends on the individual." While it is undoubtedly an excellent product,

the results can vary significantly depending on what concerns you have, which area is treated, and how the procedure is performed.

That is why we do not recommend it to everyone.

We certainly advise it for those who would benefit, but if another treatment is a better fit, we may even advise against it.

Here at Cordia Clinic in Dogok-dong, let me explain the honest reasons why.

<Treatment Philosophy>

First, let's clear up a common misconception.

Re2O is not a dermal filler; it is a skin booster.

Why is this distinction so important? Because patients often come in saying, "Please help restore my lost volume."

However, Re2O is not intended for direct volume augmentation.

Within the dermal layer, there is a structural framework known as the ECM (extracellular matrix), which consists of interwoven collagen, elastin, and hyaluronic acid.

As we age, this structure gradually deteriorates, causing the skin to thin out, lose elasticity, and develop fine wrinkles.

Re2O is a skin booster designed to directly supplement and replenish this compromised ECM from the outside.

Its primary active component, hADM (human Acellular Dermal Matrix), is derived from human dermis with all cells and immunogenic factors removed, while leaving the natural collagen and elastin architecture intact.

Whereas conventional skin boosters stimulate collagen production indirectly using substances like PDRN (salmon DNA) or PLLA (synthetic compounds), Re2O is conceptually much closer to directly grafting the essential structural matrix itself.

This fundamental difference in approach is precisely why inquiries about the procedure have surged at our Dogok-dong clinic.

Here is the key point to consider.

Re2O delivers its greatest benefits for individuals experiencing the following:

When the face feels depleted and lacks vitality, creating a need to restore inner density

When fine lines, reduced elasticity, and dull skin tone occur simultaneously

When you have tried dermal fillers or thread lifting, but were left wanting because overall skin texture remained unchanged

Conversely, if you need structural volume replenishment—such as for sunken cheeks or deep nasolabial folds—or if you desire sharp contouring around the nose tip or chin, a hyaluronic acid filler is far more suitable.

Rather than thinking, "Re2O is popular, so it must be good for me," the first question should always be, "Is my skin thinning, and do I need internal structural replenishment?"

That is why consultations at our Dogok-dong clinic always begin with this fundamental assessment.

Why do results vary depending on the practitioner's technique?

Because the outcome depends far more on the precise depth of injection than on the product alone.

Here is why:

hADM genuinely triggers neocollagenesis at the injection site.

This has been clinically verified.

Published studies have demonstrated that micronized hADM serves as a scaffold for collagen synthesis, effectively promoting tissue regeneration.

However, the cellular response changes drastically depending on the exact layer where it is delivered.

If placed too shallowly in the superficial dermis, it may cause visible nodules or surface marks.

Conversely, if delivered too deeply, it cannot interact with the dermal microenvironment required for activation, significantly diminishing the regenerative response.

The optimal target is the precise micro-layer between the mid-to-deep dermis and the subcutaneous boundary.

Pinpointing this exact layer is the first critical hurdle.

Furthermore, facial anatomy is never perfectly symmetrical, and dermal thickness varies from area to area.

A delicate area like the under-eye cannot be approached in the same manner as a thicker region like the cheek.

Injection depth and volume distribution must be customized for each patient and each distinct facial zone.

This is why we emphasize that Re2O is highly dependent on practitioner skill and manual technique.

It also explains why our Dogok-dong clinic dedicates ample time to thorough consultation and diagnostic evaluation.

Determining which layer to target and how much product to place accounts for fully 80% of the clinical outcome.

Therefore, before making a decision on any procedure, you should have sufficient time to ask questions and receive comprehensive explanations.

Walking through that thoughtful process together is the essence of genuine medical care.

If you have any remaining questions after reading this, please feel free to leave a comment below.

I will personally provide an answer through the comments or during a 1:1 consultation.

Thank you.

This has been Dr. Dajeong Kim, Chief Medical Director at Cordia Clinic, Dogok-dong.

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